首页> 外国专利> METHOD OF GENETIC DIAGNOSTICS OF UNFAVOURABLE OUTCOME IN PATIENTS WITHIN ONE YEAR AFTER ACUTE CORONARY SYNDROME WITH ST SEGMENT ELEVATION

METHOD OF GENETIC DIAGNOSTICS OF UNFAVOURABLE OUTCOME IN PATIENTS WITHIN ONE YEAR AFTER ACUTE CORONARY SYNDROME WITH ST SEGMENT ELEVATION

机译:急性冠脉综合征合并ST段抬高一年内患者不良结局的遗传诊断方法

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of medicine, namely to cardiology. In order to perform genetic diagnostics of unfavourable outcome in patients within one year after acute coronary syndrome with ST segment elevation, analysis of polymorphic candidate genes of cardiovascular diseases and risk stratification on the basis of point estimation system are performed. Determined are: genotypes of polymorphic version of rs429I gene of angiotensin-converting enzyme (ACE), polymorphic version of rs6025 gene of V clotting factor (F5), as well as genotypes of polymorphic version of rs5918 gene of platelet glycoprotein IIIa (IGTB3). Identified genotype TT by polymorphism ts4291 (ACE gene) is assessed as 2 points, genotype AT is assessed as 1 point, genotype AA - as 0 points; genotype TT by polymorphic rs6025 (F5 gene) - as 2 points, genotype CT - as 1 point, genotype CC - as 0 points; genotype CC of polymorphism of rs5918 IGTB3 gene is given 2 points, genotype CT - 1 point, and genotype TT - 0 points. Minimal risk of development of unfavourable events is determined when the sum of points equals 0-1, medium risk when the sum of points equals 2, and high risk, when the sum of points equals 3-4.;EFFECT: method makes it possible to predict development of unfavourable outcome in patients 12 months after acute coronary syndrome with segment ST elevation and perform risk stratification on the basis of point system of assessment by results of analysis of markers of candidate genes of cardiovascular diseases.;3 tbl, 2 ex
机译:技术领域本发明涉及医学领域,即心脏病学。为了对ST段抬高的急性冠脉综合征后一年内的患者进行不良转归的遗传学诊断,基于点估计系统对心血管疾病的多态性候选基因进行了分析,并进行了风险分层。确定的是:血管紧张素转化酶(ACE)的rs429I基因的多态性的基因型,V凝血因子(F5)的rs6025基因的多态性的基因型,以及血小板糖蛋白IIIa(IGTB3)的rs5918基因的多态性的基因型。通过多态性ts4291(ACE基因)鉴定的基因型TT评估为2分,基因型AT评估为1分,基因型AA-为0分;多态性rs6025(F5基因)的基因型TT-为2分,基因型CT-为1分,基因型CC-为0分; rs5918 IGTB3基因多态性的基因型CC为2分,基因型为CT-1分,基因型为TT-0分。当总分等于0-1时,确定发生不利事件的风险最小;当总分等于2时,确定中等风险;当总分等于3-4时确定高风险。通过对心血管疾病候选基因标志物的分析结果,在评估点系统的基础上预测急性冠状动脉综合征ST段抬高12个月后患者的不良结局发展,并进行风险分层。3tbl,2 ex

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