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Photoacoustic microscopy for bioimaging FUNCTIONAL

机译:光声显微镜用于生物成像功能

摘要

Optoacoustic microscope allows the photoacoustic imaging of biological tissues in vivo. It consists of a device for generating a pulsed optical radiation delivery device of pulsed optical radiation to the test site environment for local excitation in the test site environment optoacoustic pulses represent a fiberoptic bundle, an analog-digital converter connected to for normalization device emits power and synchronization focusable and an acoustic sensor, a confocal illumination radiation, as well as the test object scanning system focal constriction acoustic sensor due to mechanical displacement of the acoustic sensor assembly to the outputs of the fiber optic harness inside fixed stationary relative to the immersion chamber of the test object. The application of the utility model is possible to visualize the spatial distribution of endogenous (melanin, hemoglobin, lipids) and exogenous (methylene blue, indocyanine green, nanoparticles) dyes with a resolution of less than 100 microns at a depth of at least 3 mm for various types of functional bioimaging (determination levels oxidized and non-oxidized hemoglobin, a molecular imaging of cancer cells). Achieved by technical parameters allow the use of utility model designed primarily for functional bioimaging small laboratory animals in experimental oncology problems.
机译:光声显微镜可以在体内对生物组织进行光声成像。它包括一个生成脉冲光辐射的设备,该设备将脉冲光辐射传送到测试现场环境,以便在测试现场环境中进行局部激发,光声脉冲代表光纤束,与之相连的模数转换器用于归一化设备发射功率,同步可聚焦和声传感器,共焦照明辐射以及测试对象扫描系统的聚焦收缩声传感器,这是由于声传感器组件相对于光纤线束的输出(相对于浸没腔固定在内部)的机械位移测试对象。本实用新型的应用可以在至少3mm的深度可视化分辨率小于100微米的内源性(黑色素,血红蛋白,脂质)和外源性(亚甲基蓝,吲哚菁绿,纳米颗粒)染料的空间分布。用于各种类型的功能性生物成像(确定氧化和非氧化血红蛋白的水平,癌细胞的分子成像)。通过技术参数达到的目的是允许将实用新型设计为主要用于功能性生物成像小型实验动物的实验肿瘤学问题。

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