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METHODS AND COMPOSITIONS FOR IMPROVING MECHANICAL DURABILITY OF TEETH

机译:改善牙齿机械耐久性的方法和组成

摘要

1. A composition comprising: a) an isolated theobromine or a salt or a double salt thereof; b) at least one calcium source; c) at least one phosphate source; and d) a pH of from about 6.0 to about 8.5.2. The composition of claim 1, wherein said at least one calcium source is selected from the group consisting of calcium chloride, calcium carbonate, calcium gluconate, calcium phosphate, and combinations thereof. The composition according to claim 1, wherein said at least one phosphate source is selected from the group consisting of potassium dihydrogen phosphate, potassium hydrogen phosphate, tripotassium phosphate, sodium dihydrogen phosphate, sodium hydrogen phosphate, trisodium phosphate, and combinations thereof. The composition of claim 1, further comprising at least one isotonic agent. The composition according to claim 4, characterized in that said isotonic agent is a polyhydric alcohol. The composition of claim 5, wherein said polyhydric alcohol is selected from the group consisting of xylitol, sorbitol, mannitol, maltitol, lactitol, isomalt, erythritol, arabitol, glycerol, and combinations thereof. The composition of claim 1, further comprising at least one thickener. The composition of claim 7, wherein said thickener is selected from the group consisting of methyl cellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, and combinations thereof. The composition of claim 1, further comprising an antibacterial agent, an antimicrobial agent, or combinations thereof. The composition of claim 9, wherein said antibacterial agent is selected from the group consisting of triclosan, hydrogen peroxide, methyl 4-hydroxybenzoate, clove oil and their combination
机译:1.一种组合物,其包含:a)分离的可可碱或其盐或复盐;和b)至少一种钙源; c)至少一种磷酸盐源; d)pH为约6.0至约8.5.2。 2.权利要求1的组合物,其中所述至少一种钙源选自氯化钙,碳酸钙,葡萄糖酸钙,磷酸钙及其组合。 2.根据权利要求1的组合物,其中所述至少一种磷酸盐源选自磷酸二氢钾,磷酸氢钾,磷酸三钾,磷酸二氢钠,磷酸氢钠,磷酸三钠及其组合。 2.权利要求1的组合物,其进一步包含至少一种等渗剂。 5.根据权利要求4所述的组合物,其特征在于,所述等渗剂是多元醇。 6.权利要求5的组合物,其中所述多元醇选自木糖醇,山梨糖醇,甘露糖醇,麦芽糖醇,乳糖醇,异麦芽糖醇,赤藓糖醇,阿拉伯糖醇,甘油及其组合。权利要求1的组合物,进一步包含至少一种增稠剂。 8.根据权利要求7所述的组合物,其中,所述增稠剂选自甲基纤维素,羧甲基纤维素,乙基纤维素,羟丙基纤维素及其组合。 2.权利要求1的组合物,其进一步包含抗菌剂,抗微生物剂或其组合。 10.根据权利要求9所述的组合物,其中所述抗菌剂选自三氯生,过氧化氢,4-羟基苯甲酸甲酯,丁香油及其组合。

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