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EFFECTIVE COMBINATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS AND MINOCYCLINE IN MULTIPLE SCLEROSIS
EFFECTIVE COMBINATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS AND MINOCYCLINE IN MULTIPLE SCLEROSIS
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机译：人骨髓间充质干细胞与吗啉在多发性硬化症中的有效结合
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摘要
The present invention relates to an administration of both human bone marrow mesenchymal stem cells (hBM-MSCs) and Minocycline. The Minocycline improves a clinical magnitude of multiple sclerosis, exhibits good effects for anti-inflammation, nerve protection, and long-term use, yet has toxicity in CNS. The hBM-MSCs have shown immunity adjusting functions and nerve protecting functions. Compared to when Minocycline or hBM-MSCs are individually used, a remarkable decrease is exhibited in a clinical score when both Minocycline and hBM-MSCs are administrated. Moreover, when both Minocycline and hBM-MSCs are administrated, immunity adjusting effects are reinforced, and inflammatory cytokines (IFN-, TNF-) are controlled. In contrast, anti-inflammatory cytokines (IL-4, IL-10) are increased. Furthermore, when both Minocycline and hBM-MSCs are administrated, the number of dead cells is remarkably decreased through TUNEL coloring compared to individual administration. When both Minocycline and hBM-MSCs are administrated, provided is a protocol of a new technique for treating multiple sclerosis.
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