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The transformant for using vaccination against rotavirus and vaccine composition comprising the same

机译:用于轮状病毒疫苗接种的转化子和包含其的疫苗组合物

摘要

The present invention is a vaccine composition containing this transformant and inducing effect on rotavirus vaccines of such, and more particularly the present invention provides a transformant producing a rotavirus antigen VP7 protein is produced by introducing a gene encoding the rotavirus VP7 antigen VP7 protein coating plant or the like; An expression vector for producing the transformant; Separated from the transformant the recombinant rotavirus antigen VP7 protein; Relates to a vaccine for rotavirus disease treatment and prevention of the protein or the transformant as an active ingredient. There transformant producing rotavirus VP7 antigen protein of the present invention can be used as vaccines can induce antibody formation to prevent the occurrence of rotavirus in human rotavirus disease. In addition, production of the vaccine of the recombinant production, and rotavirus VP7 antigen protein of the present invention can be mass-produced at a low cost, and easy to store, maintain, and be able to move can be administered orally as well as the inconvenience of scanning inoculation and can save money and have an excellent effect in the induction of immune responses minister. ;
机译:本发明是一种疫苗组合物,其含有该转化子并对其产生轮状病毒疫苗的诱导作用,更具体地,本发明提供了一种通过引入编码轮状病毒VP7抗原VP7蛋白包被植物的基因而产生轮状病毒抗原VP7蛋白的转化子。类似;用于产生转化体的表达载体;从转化体中分离出重组轮状病毒抗原VP7蛋白;与轮状病毒疾病治疗和预防蛋白质或转化体为有效成分的疫苗有关。有本发明的产生轮状病毒VP7抗原蛋白的转化体可以用作疫苗,可以诱导抗体形成,以防止人轮状病毒病中轮状病毒的发生。另外,本发明的重组生产的疫苗和轮状病毒VP7抗原蛋白的生产可以低成本地大量生产,并且易于口服,保存和维护,并且能够移动。扫描接种的不便,可以省钱,并在诱导免疫反应方面有极好的效果。 ;

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