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A composition for differentiating natural killer cell or enhancing natural killer cell activation containing tanshinone as active ingredient
A composition for differentiating natural killer cell or enhancing natural killer cell activation containing tanshinone as active ingredient
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机译:包含丹参酮作为活性成分的用于分化自然杀伤细胞或增强自然杀伤细胞活化的组合物
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摘要
The present invention relates to a composition containing tanshinone as an active ingredient, for increasing a differentiation or activity of natural killer (NK) cells. More particularly, the present invention relates to a composition in which cryptotanshinone or tanshinone IIA induces and promotes a differentiation of NK cells and increases an expression of ID2 which is a gene relating to an NK cell differentiation in hematopoietic stem cells. The cryptotanshinone or tanshinone IIA has cytotoxicity to YAC-1, which is a cancer cell, and also increases generation of IFN-gamma, thus increasing the activity of NK cells. Therefore, the cryptotanshinone or tanshinone IIA can be effectively used as an active ingredient for a composition for increasing a differentiation or activity of NK cells.
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