首页> 外国专利> A composition for differentiating natural killer cell or enhancing natural killer cell activation containing tanshinone as active ingredient

A composition for differentiating natural killer cell or enhancing natural killer cell activation containing tanshinone as active ingredient

机译:包含丹参酮作为活性成分的用于分化自然杀伤细胞或增强自然杀伤细胞活化的组合物

摘要

The present invention relates to a composition containing tanshinone as an active ingredient, for increasing a differentiation or activity of natural killer (NK) cells. More particularly, the present invention relates to a composition in which cryptotanshinone or tanshinone IIA induces and promotes a differentiation of NK cells and increases an expression of ID2 which is a gene relating to an NK cell differentiation in hematopoietic stem cells. The cryptotanshinone or tanshinone IIA has cytotoxicity to YAC-1, which is a cancer cell, and also increases generation of IFN-gamma, thus increasing the activity of NK cells. Therefore, the cryptotanshinone or tanshinone IIA can be effectively used as an active ingredient for a composition for increasing a differentiation or activity of NK cells.
机译:本发明涉及包含丹参酮作为活性成分的组合物,其用于增加自然杀伤(NK)细胞的分化或活性。更具体地,本发明涉及一种组合物,其中隐丹参酮或丹参酮IIA诱导和促进NK细胞的分化并增加ID2的表达,ID2是与造血干细胞中的NK细胞分化有关的基因。隐丹参酮或丹参酮IIA对作为癌细胞的YAC-1具有细胞毒性,并且还增加了IFN-γ的产生,从而增加了NK细胞的活性。因此,隐丹参酮或丹参酮IIA可以有效地用作用于增加NK细胞的分化或活性的组合物的活性成分。

著录项

  • 公开/公告号KR101400900B1

    专利类型

  • 公开/公告日2014-05-29

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20120007819

  • 发明设计人 최인표;김원삼;권병목;

    申请日2012-01-26

  • 分类号A61K31/58;A61K31/343;A61K31/34;A61K36/258;

  • 国家 KR

  • 入库时间 2022-08-21 15:40:52

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