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首页> 外国专利> SOLID-STATE NMR PROBE FOR ANALYZING THE STRUCTURE OF A CELL MEMBRANE PROTEIN

SOLID-STATE NMR PROBE FOR ANALYZING THE STRUCTURE OF A CELL MEMBRANE PROTEIN

机译：固态NMR探针用于分析细胞膜蛋白的结构

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摘要

The present invention relates to a solid-state NMR probe capable of solving problems which can be generated when the structure analysis of cell membrane protein is executed using a solid-state NMR spectrum experiment. The disclosed solid-state NMR probe covers a material which covers the sample of the protein to analyze the structure of the cell membrane protein through the solid-state NMR spectrum experiment and includes a coil module realized with a coil which applies a magnetic field to the sample. The inside of the material is punched and is realized with insulants, and a conductor is overlaid on the surface of the material. The probe according to the present invention blocks heat to the sample with the increase of an additional magnetic field strength according to the strength increase of the magnetic field which is generated when an RF current pulse including very high current power (very high vibration number) is applied to a solid-state NMR spectrum experiment device. The probe can obtain a structure analysis result (spectrum) including high resolution in a very high magnetic field environment with the RF current pulse. The probe can improve efficiency, effectiveness, minuteness, and reliability in the investigation into the structure of the cell membrane protein.
机译：固态NMR探针技术领域本发明涉及一种固态NMR探针，其能够解决使用固态NMR光谱实验进行细胞膜蛋白质的结构分析时可能产生的问题。所公开的固态NMR探针覆盖了一种材料，该材料覆盖了蛋白质的样品，以通过固态NMR光谱实验来分析细胞膜蛋白质的结构，并且包括一个线圈模块，该线圈模块由一个向线圈施加磁场的线圈实现。样品。将材料的内部打孔并用绝缘材料制成，并在材料表面上覆盖导体。根据本发明的探针根据当包括非常高的电流功率（非常高的振动数）的RF电流脉冲产生时产生的磁场的强度增加而随着附加磁场强度的增加而阻挡对样品的热。应用于固态NMR光谱实验装置。该探针可以利用RF电流脉冲在非常高的磁场环境中获得包括高分辨率的结构分析结果（光谱）。该探针可以提高细胞膜蛋白结构研究的效率，有效性，微小性和可靠性。

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