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COMBINATION OF A RTK INHIBITOR WITH AN ANTI - ESTROGEN AND USE THEREOF FOR THE TREATMENT OF CANCER
COMBINATION OF A RTK INHIBITOR WITH AN ANTI - ESTROGEN AND USE THEREOF FOR THE TREATMENT OF CANCER
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机译：RTK抑制剂与抗雌激素的结合及其在癌症治疗中的应用。
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摘要
A pharmaceutical combination comprising (a) a RTK inhibitor selected from the group consisting of compounds of Formula I or a tautomer thereof, compounds of Formula II or a tautomer thereof, compounds of Formula III or a tautomer thereof, a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable salt of the tautomer, or a mixture thereof; and (b) one or more anti-estrogen compounds, or a pharmaceutically acceptable salt thereof; such as tamoxifen, toremifene, fulvestrant, raloxifene or raloxifene hydrochloride; the uses of such combination in the treatment or prevention of proliferative diseases: and methods of treating a subject suffering from a proliferative disease; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.
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