首页> 外国专利> BIOMARKER COMPOSITION FOR DIAGNOSIS OF BORTEZOMIB RESISTANCE COMPRISING SUPEROXIDE DISMUTASE 2 AND DIAGNOSTIC KIT USING THE SAME

BIOMARKER COMPOSITION FOR DIAGNOSIS OF BORTEZOMIB RESISTANCE COMPRISING SUPEROXIDE DISMUTASE 2 AND DIAGNOSTIC KIT USING THE SAME

机译:诊断含超氧化物歧化酶2和诊断试剂盒的博妥昔单抗耐药性的生物标记组合物

摘要

The present invention relates to a biomarker composition for diagnosing resistance of bortezomib with superoxide dismutase 2 (SOD2) as a medicine for multiple myeloma and to a kit using the same, providing a SOD2 gene, protein expressed from the gene, or the biomarker composition for diagnosing the bortezomib resistance including a particular antibody and the kit for diagnosing bortezomib resistance including the composition. The method for diagnosing bortezomib resistance comprises a step of comparing a control group with the mRNA expression level of the SOD2 gene from samples of patients with multiple myeloma or the measured expression level of protein coded by the SOD2 gene.
机译:用于诊断硼替佐米对多发性骨髓瘤的药物的超氧化物歧化酶2(SOD2)的耐药性的生物标志物组合物及使用该组合物的试剂盒,其提供了SOD2基因,从该基因表达的蛋白质或用于该药物的生物标志物组合物。诊断包括特定抗体的硼替佐米耐药性的试剂盒和包括该组合物的诊断硼替佐米耐药性的试剂盒。诊断硼替佐米抗性的方法包括将对照组与患有多发性骨髓瘤的患者样品中SOD2基因的mRNA表达水平或由SOD2基因编码的蛋白质的测量表达水平进行比较的步骤。

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