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BRAIN TARGETING NANO-CARRIER CONTAINING PLUORONIC POLYMER COMPRISING BRAIN TARGETING PEPTIDE CAPABLE OF SPECIFICE DELIVERY TO BRAIN TISSUE AND CHITOSAN
BRAIN TARGETING NANO-CARRIER CONTAINING PLUORONIC POLYMER COMPRISING BRAIN TARGETING PEPTIDE CAPABLE OF SPECIFICE DELIVERY TO BRAIN TISSUE AND CHITOSAN
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机译:包含可特定递送至脑组织和壳聚糖的脑靶向肽的脑靶向含含氟聚合物的纳米载体
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摘要
The present invention relates to a brain targeting nano-carrier comprising a pluoronic polymer which is partially substituted with chitosan combined with a brain tissue targeting peptide, and brain targeting delivery using the same. According to the present invention, the brain targeting nano-carrier comprising a pluoronic polymer having chitosan combined with a brain tissue targeting peptide is effective in the brain targeting passing through BBB and the drug delivery in a bio-active state. Further, the synergic effect of the peptide having a predetermined brain targeting sequence and chitosan can significantly enhance the targeting effect and extend the accumulation in the brain. Accordingly, the nano-carrier of the present invention is useful as a brain targeting carrier by being combined with protein and genetic material as well as other treatment agents in the future. [Reference numerals] (AA) Chitosan-funtionalized-NC (Chito-NC)
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