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ANTI-MIC-1 MONOCLONAL ANTIBODY, MBM-14 THAT INHIBITS ANGIOGENESIS-INDUCING ROLE OF MIC-1
ANTI-MIC-1 MONOCLONAL ANTIBODY, MBM-14 THAT INHIBITS ANGIOGENESIS-INDUCING ROLE OF MIC-1
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机译：抗MIC-1单克隆抗体MBM-14抑制MIC-1的血管生成诱导作用。
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摘要
The present invention relates to an anti-MIC-1 monoclonal antibody, MBM-14 inhibiting angiogenesis of MIC-1, and more specifically, to an antibody which specifically combines to MIC-1 containing a light chain variable region with amino acid sequences 1,2 and 3 on complementarity determining regions which are CDR1, CDR2 and CDR3 and heavy chain variable region with amino acid sequences 4,5 and 6 on complementarity determining regions which are CDR1, CDR2 and CDR3. The antibody of the present invention is capable of effectively suppressing angiogenesis induced by MIC-1. Therefore, growth and metastasis of tumors can be stopped, and by using the present invention, treatments can be possible not only cancer, but also diseases related to angiogenesis such as arthritis, diabetes, retina disease, arteriosclerosis and psoriasis. Such treatments can be possible since the antibody of the present invention specifically combines to MIC-1 to disturb combination between MIC-1 and a receptor. In addition, antibodies with improved treatments effects can be invented based on the information of the antibody of the present invention.
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