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首页> 外国专利> MONITORING KIT FOR IMMUNE STATUS AFTER TRANSPLANTATION AND METHOD FOR MONITORING IMMUNE STATUS USING SAME

MONITORING KIT FOR IMMUNE STATUS AFTER TRANSPLANTATION AND METHOD FOR MONITORING IMMUNE STATUS USING SAME

机译：移植后免疫状态的监测工具包和使用相同方法监测免疫状态的方法

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摘要

The present invention relates to a monitoring kit for an immune status after transplantation, and more particularly, a monitoring kit for the immune status after the transplantation, containing materials for measuring Th17 cells, Treg cells, Th1 cells, CD8EM(CD8 effect memory) IFN-γ-positive cells, and CD8CM(CD8 central memory) IFN-γ-positive cells, and a monitoring method for the immune status of the individual receiving the transplantation including a step of measuring the cell number of Th17 cells, Treg cells, Th1 cells, CD8EM IFN-γ-positive cells, and CD8CM IFN-γ-positive cells against the peripheral blood of an object receiving the transplantation, and a step for calculating each cell number ratio of Treg cells, Th1 cells, CD8EM IFN-γ-positive cells, and CD8CM IFN-γ-positive cells against the number of Th17 cells by dividing the measured values of cell numbers of Treg cells, Th1 cells, CD8EM IFN-γ-positive cells, and CD8CM IFN-γ-positive cells with the measured value of the cell number of Th17 cells. The monitoring method and kit for the immune status of the individual receiving the transplantation provided by the present invention are capable of determining the immune status with ease and accuracy, thereby reducing the excessive use of an immunosuppressant prescribed after transplantation and managing the immune status of each patient.;COPYRIGHT KIPO 2014;[Reference numerals] (AA,EE,II,MM,QQ,UU) Normally take CNI (100% taking);(BB,DD,FF,HH,JJ,LL,NN,PP,RR,TT,VV,XX) Reduce CNI by 25% (75% taking);(CC,GG,KK,OO,SS,WW) Reduce CNI 50% (50% taking)
机译：本发明涉及用于移植后免疫状态的监测试剂盒，更具体地，涉及用于移植后免疫状态的监测试剂盒，其包含用于测量Th17细胞，Treg细胞，Th1细胞，CD8EM（CD8效应记忆）IFN的材料-γ阳性细胞和CD8CM（CD8中央记忆）IFN-γ阳性细胞，以及接受移植的个体的免疫状况的监测方法，包括测量Th17细胞，Treg细胞的细胞数的步骤，Th1细胞，CD8EMIFN-γ阳性细胞和CD8CMIFN-γ阳性细胞对抗接受移植的对象的外周血，以及计算Treg细胞，Th1细胞和CD8EM的每种细胞数比的步骤通过将Treg细胞，Th1细胞，CD8EMIFN-γ阳性细胞和CD8CM IFN的细胞数的测量值除以IFN-γ阳性细胞和CD8CMIFN-γ阳性细胞对Th17细胞的数量-＆-; posi活跃的细胞与Th17细胞的细胞数的测量值。本发明提供的用于接受移植的个体的免疫状况的监测方法和试剂盒能够容易且准确地确定免疫状况，从而减少了移植后处方的免疫抑制剂的过量使用并管理了每种免疫状况。患者。; COPYRIGHT KIPO 2014; [参考数字]（AA，EE，II，MM，QQ，UU）通常服用CNI（100％服用）;（BB，DD，FF，HH，JJ，LL，NN，PP， RR，TT，VV，XX）使CNI降低25％（占75％）;（CC，GG，KK，OO，SS，WW）使CNI降低50％（占50％）

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