首页> 外国专利> Patch comprising oxybutynin hydrochloride and method for producing the same

Patch comprising oxybutynin hydrochloride and method for producing the same

机译:包含盐酸奥昔布宁的贴剂及其制备方法

摘要

A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising:a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier;a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70°C for 1 to 24 hours; anda step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20°C/hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.
机译:一种生产贴剂的方法,该贴剂包括支撑层和布置在该支撑层的至少一个表面上的粘合剂层,该方法包括:步骤A,获得粘合剂层组合物,其包含盐酸奥昔布宁作为药物,丙烯酸类聚合物和/或橡胶类聚合物作为粘合剂,液体石蜡,固醇,有机酸和增粘剂;步骤B:在55至70℃的温度下加热粘合剂层组合物1至24小时;和步骤C,以1至20℃/小时的平均降温速率将加热的粘合剂层组合物冷却至低于室温的温度,从而获得包含处于溶解状态的过饱和浓度的药物的粘合剂层形成。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号