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Glycomic Signatures on Serum IgGs after Influenza Vaccination

机译:流感疫苗接种后血清IgG的糖原性特征

摘要

#$%^&*AU2014100769A420140731.pdf#####GLYCOMIC SIGNATURES ON SERUM IgGs AFTER INFLUENZA VACCINATION ABSTRACT The present invention provides a comprehensive analysis on the glycosylation of serum IgGs after vaccination against influenza. Analysis of the subclass-specific glycosylation at the glycopeptide level is achieved with trypsin digestion and UHIPLC-ESI-QqQ MS in the multiple reaction monitoring mode. The present invention also provides a method of identifying a subject with the likelihood to generate immune response after vaccination based on the marker glycoforms in the glycosylation profile. DocRef#00120293-CP M006.034.DRF 27 Spec Final Version
机译:#$%^&* AU2014100769A420140731.pdf #####感染后血清IgG的糖脂信号接种疫苗抽象本发明提供了对血清糖基化的全面分析接种流感疫苗后的IgG。亚类特异性糖基化的分析通过胰蛋白酶消化和UHIPLC-ESI-QqQ MS可以达到糖肽水平多反应监测模式。本发明还提供了一种识别接种疫苗后可能产生免疫反应的受试者基于糖基化概况中的标记糖型。M006.034.DRF 27 Spec最终版本

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