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Remodeling and glycoconjugation of human growth hormone (hGH)

机译：人类生长激素（hGH）的重塑和糖结合

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摘要

An in vitro procedure without cells to form a conjugate between a human growth hormone (HGH) peptide and a modifying group, in which the modifying group is not a sugar of the modifying group is covalently linked to the glycopeptide by a group of intact glycosyl bond, the glycopeptide comprising a glycosyl moiety having a formula that is a member selected from: ** Formula ** and in which 10 a, b, c, d, i, j, k, l, m, r, s, t, u, z, aa, bb, cc, and ee are independently selected members of 0 and 1; e, f, g and h are independently selected members of the whole numbers between 0 and 4; n, v, w, x, y, and dd are 0; R is a modifying group, a mannose or an oligomanose and; R 'is a member selected from H, a glycosyl moiety, a modifying group and a glycoconjugate, the process comprising: (a) contacting the glycopeptide with a glycosyltransferase and comprising a glycosyl moiety that is a substrate for covalently linked glycosyltransferase to the modifying group, under appropriate conditions for the formation of the intact glycosyl linking group.

机译：在没有细胞形成人生长激素（HGH）肽和修饰基团之间偶联物的体外程序中，修饰基团不是修饰基团的糖，是通过一组完整的糖基键与糖肽共价连接的，包含具有下式的糖基部分的糖肽，该下式的成员选自：** **，并且其中10 a，b，c，d，i，j，k，l，m，r，s，t u，z，aa，bb，cc和ee是0和1的独立选择的成员; e，f，g和h是0到4之间整数的独立选择的成员; n，v，w，x，y和dd为0; R为修饰基团，甘露糖或寡甘露糖，并且; R'是选自H，糖基部分，修饰基团和糖缀合物的成员，该方法包括：（a）使糖肽与糖基转移酶接触并且包含作为共价连接的糖基转移酶与修饰基团的底物的糖基部分。，在适当条件下形成完整的糖基连接基团。

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公开/公告号ES2516041T3

专利类型
公开/公告日2014-10-30

原文格式PDF
申请/专利权人 RATIOPHARM GMBH;
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申请/专利号ES20100012938T
发明设计人 DE FREES SHAWN;ZOPF DAVID;BAYER ROBERT;BOWE CARYN;HAKES DAVID;CHEN XI;
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申请日2002-10-09
分类号A61K47/48;C12N15/09;A61K38;A61K38/14;A61K38/16;A61K38/21;A61K38/22;A61K38/24;A61K38/26;A61K38/27;A61K38/28;A61K38/29;A61K38/30;A61K38/43;A61K38/46;A61K38/48;A61K38/55;A61K39/395;A61P1/16;A61P3/10;A61P5/10;A61P7/04;A61P7/06;A61P19/10;A61P29;A61P31/04;A61P31/10;A61P31/12;A61P31/14;A61P31/16;A61P31/18;A61P31/20;A61P35;A61P37/04;A61P37/08;A61P43;C07H19/10;C07K1;C07K1/107;C07K1/13;C07K9;C07K14;C07K14/47;C07K14/475;C07K14/505;C07K14/525;C07K14/535;C07K14/55;C07K14/56;C07K14/565;C07K14/57;C07K14/59;C07K14/61;C07K14/62;C07K14/705;C07K14/715;C07K14/755;C07K14/79;C07K14/81;C07K16/08;C07K16/18;C07K16/24;C07K16/28;C07K19;C12N9/16;C12N9/22;C12N9/26;C12N9/42;C12N9/64;C12N9/72;C12P19/26;C12P21;C12P21/02;C12P21/06;C12P21/08;
国家 ES
入库时间 2022-08-21 15:54:57

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