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intracranial catheters optimized for delivery of therapeutic agents convection-enhanced

机译:颅内导管经过优化,可增强对流治疗药物的输送

摘要

Set cebable catheter for use in applications targeted drug delivery, the assembly comprising: a catheter (20) having an inner lumen (30), one end (22) of base, one end (24) edge a internal diameter (70) and an outer diameter, having a portion of the outer diameter a first surface (92) corresponding to the beveled tip end of the catheter, and having the inner diameter a corresponding tapered portion also to the tip end of the catheter; and a trocar (40) slidably positioned within the catheter (20) and include a 10 first end, a second end and a diameter (49) external, further comprising the first end having a tip extending beyond the end ( 24) of the catheter tip, and the second end beyond the end (22) of catheter base, with the outer diameter (49) extending the trocar smaller than the inner diameter of the tapered portion (70) of the catheter; wherein a portion of light (30) internally comprises a reservoir (60) of fluid having said first diameter (70) inside, comprising a distal end (62) of the reservoir (60) of fluid an opening (64) through of which may be injected a fluid (50) priming in and through the lumen (30) inside, comprising a proximal end (66) of the fluid reservoir a narrowing (80) bevelled reducing the first diameter (70) internal to said second diameter (72) corresponding to a portion (82) of the catheter tip (20) further including end (66) proximal an aperture (84) through a fluid exiting the catheter (20); the outer diameter (49) of the trocar (40) is less than the second diameter (72) inside the catheter so that a gap (90) cebable between the surface (52) external of the trocar and the inner surface (34) is provided, providing a hollow unobstructed passage through the lumen (30) through which a fluid can be injected (50) priming by light (30) internal to displace air trapped within the catheter (20).
机译:一种用于目标药物输送的可塞入导管,该组件包括:导管(20),其具有内腔(30),基部的一端(22),边缘(24)的内径(70)和一个外径,具有一部分外径的第一表面(92),该第一表面对应于导管的斜角末端,并且具有内径,该锥形部分也对应于导管的末端;套管针(40)可滑动地定位在导管(20)内,并包括第一端,第二端和外部直径(49),进一步包括第一端,该第一端的尖端延伸超过导管的端部(24)尖端,并且第二端超出导管底部的端部(22),延伸套管针的外径(49)小于导管的锥形部分(70)的内径;其中光的一部分(30)内部包括内部具有上述第一直径(70)的流体容器(60),该流体容器包括流体容器(60)的远端(62),开口(64)可以通过该远端(62)被注入的流体(50)被灌注进入并通过内部的内腔(30),包括流体储存器的近端(66),该狭窄部分(80)成斜面,减小了所述第二直径(72)内部的第一直径(70)。对应于导管末端(20)的一部分(82),该末端还包括靠近孔(84)的端部(66),该末端(66)穿过离开导管(20)的流体;套管针(40)的外径(49)小于导管内部的第二直径(72),使得套管针外部的表面(52)和内表面(34)之间可形成的间隙(90)为如图所示,提供了穿过内腔(30)的中空无阻碍的通道,通过该内腔(30)可以注入流体(50),通过内部的光(30)引发流体,以置换被困在导管(20)内的空气。

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