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intracranial catheters optimized for delivery of therapeutic agents convection-enhanced
intracranial catheters optimized for delivery of therapeutic agents convection-enhanced
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机译:颅内导管经过优化,可增强对流治疗药物的输送
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摘要
Set cebable catheter for use in applications targeted drug delivery, the assembly comprising: a catheter (20) having an inner lumen (30), one end (22) of base, one end (24) edge a internal diameter (70) and an outer diameter, having a portion of the outer diameter a first surface (92) corresponding to the beveled tip end of the catheter, and having the inner diameter a corresponding tapered portion also to the tip end of the catheter; and a trocar (40) slidably positioned within the catheter (20) and include a 10 first end, a second end and a diameter (49) external, further comprising the first end having a tip extending beyond the end ( 24) of the catheter tip, and the second end beyond the end (22) of catheter base, with the outer diameter (49) extending the trocar smaller than the inner diameter of the tapered portion (70) of the catheter; wherein a portion of light (30) internally comprises a reservoir (60) of fluid having said first diameter (70) inside, comprising a distal end (62) of the reservoir (60) of fluid an opening (64) through of which may be injected a fluid (50) priming in and through the lumen (30) inside, comprising a proximal end (66) of the fluid reservoir a narrowing (80) bevelled reducing the first diameter (70) internal to said second diameter (72) corresponding to a portion (82) of the catheter tip (20) further including end (66) proximal an aperture (84) through a fluid exiting the catheter (20); the outer diameter (49) of the trocar (40) is less than the second diameter (72) inside the catheter so that a gap (90) cebable between the surface (52) external of the trocar and the inner surface (34) is provided, providing a hollow unobstructed passage through the lumen (30) through which a fluid can be injected (50) priming by light (30) internal to displace air trapped within the catheter (20).
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