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New 4-(4-substituted phenyl)-2-((E)-2((1R)-1,7,7-trimethyl-bicyclo 2.2.1 heptan-2-ylidene) hydrazino) thiazoles and their method of preparation
New 4-(4-substituted phenyl)-2-((E)-2((1R)-1,7,7-trimethyl-bicyclo 2.2.1 heptan-2-ylidene) hydrazino) thiazoles and their method of preparation
the subject of the invention are derivatives of 4 - (4 - podstawionefenylo) - 2 - ((e) - 2 - ((1r) - 1,7,7-trimethylbicyclo [2.2.1] heptane - ylidene) 2 hydrazino) tiazoli, intended for the treatment of patients infected grzybicami candida spp., of the formula 1 in which r = och3, h, f, br, cn, no2, nhcoch3, nhcoch2cl, nhso2ch3, ph, model 2 and model 3, and process for the production of derivatives of 4 - (4 - podstawionefenylo) - 2 - ((e) - 2 - ( (1r) - 1,7,7 trimethylbicyclo [2.2.1] heptane - 2 - ylidene) hydrazino) tiazoli, which is subjected to (1r) - (+) - camphor tiosemikarbazydem catalysed reaction with concentrated sulphuric acid in anhydrous organic solvent at boiling temperature, to obtain a tiosemikarbazonu,and then cyklizacji in inert environment obtained tiosemikarbazonu relevant 2-chloro-1 - fenyloetanonami in anhydrous organic solvent and products yields a way.
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