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HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC DETERMINATION OF COMBINED DOSAGE FORM OF SALBUTAMOL AND BECLOMETHASONE IN ROTA CAPS
HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC DETERMINATION OF COMBINED DOSAGE FORM OF SALBUTAMOL AND BECLOMETHASONE IN ROTA CAPS
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机译：高效液相色谱色谱法测定旋转囊中沙丁胺醇和倍他米松的混合剂型。
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摘要
In one of the important aspect of the invention high performance thin layer chromatography (HPTLC) method simultaneous determination of combined dosage form of Salbutamol and Beclomethasone in Rota caps, the chromatograms were developed using a mobile phase of Toluene: Ethanol: Triethyl amine (6:2:1 v/v).The method uses aluminum plates coated with silica gel 60 F254 as stationary phase. Densitometry evaluation of the separated bands was performed at 270 nm.The Revalues for Salbutamol and Beclomethasone were 0.38 and 0.82 respectively. The linearity of Salbutamol and Beclomethasone is 1600 to 9600 ng/spot and 400 to 2400 ng/spot respectively. Recovery of Salbutamol and Beclomethasone is in between 100.02 to 101.99. Precision, Robustness and Ruggedness are shown in validation section. The proposed method HPTLC method is simple, economic, accurate & reproducible & can be used in routine analysis for simultaneous determination of Salbutamol and Beclomethasone in combined dosage form.
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机译：在本发明的重要方面之一是高效薄层色谱法（HPTLC）同时测定Rota瓶中沙丁胺醇和倍氯米松的组合剂型时，使用甲苯：乙醇：三乙胺（6： 2：1 v / v）。该方法使用涂有硅胶60 F254的铝板作为固定相。在270 nm处对分离的谱带进行光密度测定评估。沙丁胺醇和倍氯米松的重估值分别为0.38和0.82。沙丁胺醇和倍氯米松的线性分别为1600至9600 ng / s和400至2400 ng / s。沙丁胺醇和倍氯米松的回收率在100.02至101.99之间。精度，稳健性和坚固性显示在验证部分。所提出的方法HPTLC方法简便，经济，准确，可重现，可用于常规分析，以同时测定联合剂型中的沙丁胺醇和倍氯米松。
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