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SOLID LIPID NANOPARTICLES AS A CARRIER FOR LERCANIDIPINE, A MECHANISM FOR TWO-WAY ENHANCEMENT OF ORAL BIOAVILABILITY
SOLID LIPID NANOPARTICLES AS A CARRIER FOR LERCANIDIPINE, A MECHANISM FOR TWO-WAY ENHANCEMENT OF ORAL BIOAVILABILITY
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机译：固体脂质纳米粒作为莱卡尼定的载体，是双向增强口服生物利用度的机制
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摘要
In this invention, lercanidipine entrapped solid lipid nanoparticles was developed comprising of Glyceryl Monostearate as solid lipid and Gelucire 44/14 as surfactant to yield a stable formulation with enhanced oral bioavailability and extended release of action. Preparation of drug loaded formulation involves the Hot-Homogenisation method. Lipid solubility of drug is an added benefit to the high entrapment efficiency. Solid lipid formulation provides enhanced physical and chemical stability of the drug molecule. High Pressure Homogenisation method is less time consuming, involves less metal contamination as compared to sonication method and hence more economical. The size of formulation was achieved between 100 - 200 nm, which is optimum to bypass the First-pass metabolism. The stability of the formulation was more than 6 months. Drug loading was achieved to be more than 90%. The Pharrnacodynamic activity was found to be controlled for more than 36 hours.
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