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N-phenyl anthranilic acid derivatives comprising a nitro substituent on the anthranilic ring and an alkylene glycol or hydroxy alkyl- containing group conjugated to the carboxylic group, pharmaceutical compositions comprising same and uses thereof in opening a voltage- dependent potassium channel and/or in depressing cortical and/or peripheral neuron activity
N-phenyl anthranilic acid derivatives comprising a nitro substituent on the anthranilic ring and an alkylene glycol or hydroxy alkyl- containing group conjugated to the carboxylic group, pharmaceutical compositions comprising same and uses thereof in opening a voltage- dependent potassium channel and/or in depressing cortical and/or peripheral neuron activity
ABSTRACT Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing or enhancing cortical and/or peripheral neuron activity, compositions containing same and methods utilizing same are disclosed. Also disclosed are modulators of voltage-dependent potassium channels, which exhibit blocking of a TRPV1 channel, and hence are useful in the treatment of TRPV1-related conditions.
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