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首页> 外国专利> Double binding molecules of BCMA and CD3; nucleic acid sequences for coding; vectors; clula; pharmaceutical ingredients including monomolecules; uses for treating diseases related to plasticizing cell degeneration, Type B cell disorders associated with BCMA manifestations and autoimmune diseases

Double binding molecules of BCMA and CD3; nucleic acid sequences for coding; vectors; clula; pharmaceutical ingredients including monomolecules; uses for treating diseases related to plasticizing cell degeneration, Type B cell disorders associated with BCMA manifestations and autoimmune diseases

机译：BCMA和CD3的双结合分子;用于编码的核酸序列;向量;克拉药物成分，包括单分子;用于治疗与塑化细胞变性，与BCMA表现有关的B型细胞疾病和自身免疫性疾病有关的疾病

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摘要

The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
机译：本发明涉及包含第一和第二结合结构域的结合分子，其中第一结合结构域能够结合BCMA的表位簇，并且第二结合结构域能够结合T细胞CD3受体复合物。此外，本发明提供了编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。此外，本发明提供了生产本发明结合分子的方法，所述结合分子的医学用途以及包含所述结合分子的试剂盒。

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