首页> 外国专利> Compounds derived from carboxylic acid substituted carbamoyl - hidroisoquinolinas, antiapoptotic Proteins BCL XL inhibitors; Pharmaceutical Composition and method of treatment for breast cancer, cervical cancer, colorectal cancer, Hepatocellular cancer, esophagus cancer, Ucemias, myelomas, among others.

Compounds derived from carboxylic acid substituted carbamoyl - hidroisoquinolinas, antiapoptotic Proteins BCL XL inhibitors; Pharmaceutical Composition and method of treatment for breast cancer, cervical cancer, colorectal cancer, Hepatocellular cancer, esophagus cancer, Ucemias, myelomas, among others.

机译：衍生自羧酸取代的氨基甲酰基-hidroisoquinolinas的化合物，抗凋亡蛋白BCL XL抑制剂;用于乳腺癌，子宫颈癌，结肠直肠癌，肝细胞癌，食道癌，尿毒症，骨髓瘤等的药物组合物和治疗方法。

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摘要

Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.

机译：公开了抑制抗凋亡Bcl-xL蛋白活性的式（I）化合物，包含该化合物的组合物和治疗表达Bcl-xL蛋白的疾病例如癌症的方法。 X是杂芳基; Y1为亚苯基或亚杂芳基; L1是链接器; Y 2是环烷基，环烯基，杂环烷基或杂环烯基; Z1是C（0）OR9，C（O）NR10R11，C（0）R11，NR10C（O）R11等。

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公开/公告号CL2014000905A1

专利类型
公开/公告日2014-09-22

原文格式PDF
申请/专利权人 ABBVIE INC.;
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申请/专利号CL20140000905
发明设计人 WANG XILU;DOHERTY GEORGE;TAO ZHI-FU;WANG LE;HANSEN TODD M;BRUNKO MILAN;KUNZER AARON R;WENDT MICHAEL D;SONG XIAHONG;FREY ROBIN;SULLIVAN GERARD M;JUDD ANDREW;SOUERS ANDREW;
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申请日2014-04-10
分类号C07D417/14;A61K31/4725;A61P35/00;C07D471/04;C07D513/04;
国家 CL
入库时间 2022-08-21 15:58:26

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