首页> 外国专利> EP2 agonists Aniline derivative Compounds, Process for preparing them and Pharmaceutical composition; Medicine; prostaglandins; combination with beta blockers, sympathomimetics, eye drops, eye drops or Carbonic Anhydrase inhibitors parasympathomimetic intermediaries; Compounds; method of t Treatment; and its use to treat glaucoma.

EP2 agonists Aniline derivative Compounds, Process for preparing them and Pharmaceutical composition; Medicine; prostaglandins; combination with beta blockers, sympathomimetics, eye drops, eye drops or Carbonic Anhydrase inhibitors parasympathomimetic intermediaries; Compounds; method of t Treatment; and its use to treat glaucoma.

机译：EP2激动剂苯胺衍生物化合物，其制备方法和药物组合物;药物;前列腺素;与β受体阻滞剂，拟交感神经药，眼药水，滴眼剂或碳酸酐酶抑制剂拟交感神经药中间体结合使用;化合物;治疗方法;及其用于治疗青光眼。

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摘要

The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.

机译：本发明涉及式（I）的苯胺衍生物，其制备及其治疗用途，例如在治疗青光眼中：式（I），R 1a代表H，卤素，（C 1 -C 6）烷基或CN ; R1b代表H，卤素或（C1-C6）烷基; R1c代表H或（C1-C6）烷基; R2代表H，卤素，OH，O（C1-C6）烷基或（C1-C6）烷基; R3代表H，卤素，（C1-C6）烷基，OH，O（C1-C6）烷基，CONH2或CN; R4代表H，卤素或（C1-C6）烷基; R5代表H或F：R7代表H或F; R8代表H或F; R9代表H或（C1-C6）烷基，或其对映异构体之一。

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公开/公告号CL2014000639A1

专利类型
公开/公告日2014-11-03

原文格式PDF
申请/专利权人 SANOFI;
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申请/专利号CL20140000639
发明设计人 FEUTRILL JOHN;LERICHE CAROLINE;MIDDLEMISS DAVID;
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申请日2014-03-14
分类号C07C217/84;A61K31/196;A61P27/06;
国家 CL
入库时间 2022-08-21 15:58:25

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