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The chemical molecule includes a multifunctional organism, including an anti-Mestolin antibody SS1P, a connector, an angry cutting field, a connector and a modified pseudopolygon A endocrine three-level functional control; pharmacodynamic synthesis; Nucleic acid; Vector; Clula Hugheside, Uses
The chemical molecule includes a multifunctional organism, including an anti-Mestolin antibody SS1P, a connector, an angry cutting field, a connector and a modified pseudopolygon A endocrine three-level functional control; pharmacodynamic synthesis; Nucleic acid; Vector; Clula Hugheside, Uses
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Pseudomonas Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which express mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
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