首页> 外国专利> 1,4-diazopropylene glycol 3,2,2-9-alkane, quinokirin, 1-aza bicycle 2,2,2-substituted octabromodiphenyl ether compounds; and compounds used as synthetic glucose inhibitors for the treatment of metabolic diseases, such as dissolution and storage, used only in combination with alternative therapy Treatment of enzymes and cancer.

1,4-diazopropylene glycol 3,2,2-9-alkane, quinokirin, 1-aza bicycle 2,2,2-substituted octabromodiphenyl ether compounds; and compounds used as synthetic glucose inhibitors for the treatment of metabolic diseases, such as dissolution and storage, used only in combination with alternative therapy Treatment of enzymes and cancer.

机译：1,4-重氮丙二醇[3,2,2] -9-烷烃，喹诺酮，1-氮杂自行车[2,2,2]-取代的八溴二苯醚化合物;以及用作合成葡萄糖抑制剂以治疗代谢性疾病（例如溶解和贮藏）的化合物，仅与替代疗法结合使用，用于治疗酶和癌症。

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摘要

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

机译：本发明涉及葡糖神经酰胺合酶（GCS）的抑制剂，其单独或与酶替代疗法联合用于治疗代谢性疾病，例如溶酶体贮积病，并用于治疗癌症。

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公开/公告号CL2013002688A1

专利类型
公开/公告日2014-03-07

原文格式PDF
申请/专利权人 GENZYME CORPORATION;
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申请/专利号CL20130002688
发明设计人 BOURQUE ELYSE;CELATKA CASSANDRA;HIRTH BRADFORD;METZ MARKUS;ZHAO ZHONG;SKERLJ RENATO;XIANG YIBIN;JANCISICS KATHERINE;MARSHALL JOHN;CHENG SENG;SCHEULE RONALD;CABRERA-SALAZAR MARIO;GOOD ANDREW;
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申请日2013-09-17
分类号C07D453/02;A61K31/439;A61P3/00;
国家 CL
入库时间 2022-08-21 15:58:28

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