首页> 外国专利> 6.7-Dialcoxi-3-isoquinol substitutes, PDE10A inhibitors; synthesis of pharmaceuticals containing these substances; and compounds used to treat metabolic disorders, SNC disorders, such as Alzheimer's disease, depression and neurodegenerative disorders They are multiple sclerosis.

6.7-Dialcoxi-3-isoquinol substitutes, PDE10A inhibitors; synthesis of pharmaceuticals containing these substances; and compounds used to treat metabolic disorders, SNC disorders, such as Alzheimer's disease, depression and neurodegenerative disorders They are multiple sclerosis.

机译:6.7-Dialcoxi-3-isoquinol替代品,PDE10A抑制剂;合成含有这些物质的药物;以及用于治疗代谢性疾病,SNC疾病(例如阿尔茨海默氏病,抑郁症和神经退行性疾病)的化合物。它们是多发性硬化症。

摘要

The invention relates to compounds of the formula wherein R, R1, through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.
机译:本发明涉及下式的化合物,其中R,R1,R7和Ar如本文所定义。这些化合物可用作磷酸二酯酶10(PDE10A)的抑制剂,其可用于治疗中枢神经系统疾病如精神病,也可用于治疗例如肥胖症,II型糖尿病,代谢综合征,葡萄糖耐受不良,疼痛和眼科疾病。

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