首页> 外国专利> Compounds derived from 2-amino-5 - (trifluoromethyl) - furo 3,4-d thiazine, as inhibitors of the production of beta Amyloid Protein; Pharmaceutical Composition and its use for treating or Preventing a neurodegenerative disease such as Alzheimer type Dementia and senile dementia, and to Treat or prevent Get Type 2 diabetes.

Compounds derived from 2-amino-5 - (trifluoromethyl) - furo 3,4-d thiazine, as inhibitors of the production of beta Amyloid Protein; Pharmaceutical Composition and its use for treating or Preventing a neurodegenerative disease such as Alzheimer type Dementia and senile dementia, and to Treat or prevent Get Type 2 diabetes.

机译:衍生自2-氨基-5-(三氟甲基)-呋喃并[3,4-d]噻嗪的化合物,它们是β淀粉样蛋白生产的抑制剂;药物组合物及其在治疗或预防神经退行性疾病如阿尔茨海默氏痴呆和老年性痴呆以及治疗或预防2型糖尿病中的用途。

摘要

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; A is CH or N; Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or CN; and pharmaceutically acceptable salts thereof; which compound has an A production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by A and typified by Alzheimer-type dementia.
机译:式(I)的稠合氨基二氢噻嗪衍生物本发明涉及式(I)的稠合氨基二氢噻嗪衍生物。 A是CH或N; Y是甲基,乙基,一氟甲基,二氟甲基,三氟甲基,二氟乙基,甲氧基,乙氧基,甲氧基甲基或CN;及其药学上可接受的盐;该化合物具有A产生抑制作用或BACE1抑制作用,并可用作由A引起的,以阿尔茨海默氏型痴呆为代表的神经退行性疾病的预防或治疗剂。

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