首页> 外国专利> ISOLATED HUMAN MONOCLONAL ANTIBODY OR ANTIGEN CONNECTION PORTION OF THE SAME, ISOLATED POLYPEPTIDE, COMPOSITION, ISOLATED NUCLEIC ACID, EXPRESSION VECTOR, HOST VECTOR, Hepatitis C, HCV VT, HCV VT HEPATITIS C (HCV) AND TO IDENTIFY ANTIBODY OR FRAGMENT OF THE SAME, ANTIBODY OR FRAGMENT OF THE SAME, AND HEPATITE C (HCV) RECOMBINANT E2 PROTEIN

ISOLATED HUMAN MONOCLONAL ANTIBODY OR ANTIGEN CONNECTION PORTION OF THE SAME, ISOLATED POLYPEPTIDE, COMPOSITION, ISOLATED NUCLEIC ACID, EXPRESSION VECTOR, HOST VECTOR, Hepatitis C, HCV VT, HCV VT HEPATITIS C (HCV) AND TO IDENTIFY ANTIBODY OR FRAGMENT OF THE SAME, ANTIBODY OR FRAGMENT OF THE SAME, AND HEPATITE C (HCV) RECOMBINANT E2 PROTEIN

机译：同一人的分离的人类单克隆抗体或抗原连接部分，分离的多肽，组成，分离的核酸，表达载体，宿主矢量，丙型肝炎，HCV VT，HCV VT肝炎C，抗体和体征相同的抗体或片段，以及C（HCV）重组E2蛋白

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Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

机译：公开了与丙型肝炎病毒（HCV）结合的分离的人单克隆抗体，以及相关的基于抗体的组合物和分子。人抗体可以在转染瘤中或在非人转基因动物例如转基因小鼠中产生，该动物能够通过进行V-D-J重组和同种型转换而产生人单克隆抗体的多种同种型。还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

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公开/公告号BRPI0807929A2

专利类型
公开/公告日2014-06-24

原文格式PDF
申请/专利权人 UNIVERSITY OF MASSACHUSETTS;
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申请/专利号BR2008PI07929
发明设计人 TERESA BROERING;SUSAN SLOAN;GREGORY J. BABCOCK;DONNA AMBROSINO;JR. WILLIAM D. THOMAS;
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申请日2008-02-13
分类号C07K16/10;A61K39;A61K39/395;A61P31/14;
国家 BR
入库时间 2022-08-21 15:58:34

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