首页> 外国专利> PHARMACEUTICAL COMPOSITION, AND METHODS FOR TREATING MALE SUBFERTILITY, FOR DETERMINING A FERTLITY STATUS IN A MALE SEX, FOR ASSISTED REPRODUCTION TECHNIQUE FOR A SPECULAR SPULLET REPRODUCTION FOR CULLED SPLIT USE IN AN AUXILIARY REPRODUCTION TECHNIQUE.

PHARMACEUTICAL COMPOSITION, AND METHODS FOR TREATING MALE SUBFERTILITY, FOR DETERMINING A FERTLITY STATUS IN A MALE SEX, FOR ASSISTED REPRODUCTION TECHNIQUE FOR A SPECULAR SPULLET REPRODUCTION FOR CULLED SPLIT USE IN AN AUXILIARY REPRODUCTION TECHNIQUE.

机译：用于辅助生殖技术的人工繁殖的人工繁殖的辅助生殖技术的药物成分和治疗男性亚生殖力的方法，确定男性性别中的生育状况的方法。

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摘要

The invention provides pharmaceutical compositions for treating male sub-fertility including an agent that causes a reduction in an effect of extracellular DNA on sperm cells. The agent may be, for example, an enzyme that degrades DNA such as DNase, a substance that blocks the interaction between cell free DNA and sperm cell surface receptors, a substance that binds to DNA, a substance that inhibits endogenous sperm cell DNase, a substance that inhibits a member of a signal transduction pathway mediated by DNA binding to sperm cell surface receptors, or an agent that stimulates production of an endogenous substance that causes a reduction in an antifertility effect of cell free DNA on sperm cells. The invention also provides methods for treating male sub-fertility comprising administering a pharmaceutical composition of the invention. The invention further provides methods for determining a fertility status in a male subject, methods for assisted reproduction, methods for selecting an assisted reproduction technique (ART), and methods for selecting sperm cells in a sperm cell population for use in an assisted reproduction technique.

机译：本发明提供了用于治疗雄性亚生育力的药物组合物，该药物组合物包括引起细胞外DNA对精子细胞作用降低的试剂。所述试剂可以是例如降解DNA的酶，例如DNase;一种阻断无细胞DNA与精子细胞表面受体之间相互作用的物质;一种与DNA结合的物质;一种抑制内源性精子DNase的物质;一种与DNA结合的物质。抑制由DNA与精子细胞表面受体结合介导的信号转导途径成员的物质，或刺激内源性物质产生的物质，该物质导致无细胞DNA对精子细胞的抗生育作用降低。本发明还提供了治疗雄性亚生育力的方法，包括施用本发明的药物组合物。本发明进一步提供了用于确定男性受试者的生育状态的方法，用于辅助生殖的方法，用于选择辅助生殖技术（ART）的方法以及用于选择用于辅助生殖技术的精细胞群中的精细胞的方法。

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公开/公告号BRPI0717439A2

专利类型
公开/公告日2013-11-19

原文格式PDF
申请/专利权人 PERINESS LTD.;
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申请/专利号BR2007PI17439
发明设计人 BENJAMIN BARTOOV;RONEN YEHUDA;MELAMED DOBROSLAV;
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申请日2007-10-18
分类号A61K45/06;A61K31;A61K31/194;A61K38/17;A61K45/08;A61P15/08;G01N33/50;
国家 BR
入库时间 2022-08-21 15:58:38

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