A Pharmaceutical composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinotecan (FOLFIRI) useful for the treatment of Colorectal Cancer (CRC).Claim 1: a method to treat colorectal cancer (CRC) or a symptom of Colorectal Cancer (CRC) in a patient in need, Said method comprising administering to said patient therapeutically effective amounts of aflibercept, folinic acid, 5-fluorouracil (5-fu) And irinotecan.Claim 24: a composition comprising therapeutically effective amounts of aflibercept in combination with folinic acid, 5-fluorouracil (5-fu) and irinotecan for Patients with CRC in the Administrations of aflibercept, folinic acid,5-fluorouracil (5-fu) and irinotecan are Spaced along a period of time to obtain the maximum efficiency of the combination.
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