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首页> 外国专利> Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria

Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria

机译：用于调节或调节细菌中群体感应的组合物，使用该化合物的方法以及调节或调节细菌中群体感应的方法

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摘要

The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
机译：本公开内容包括用作控制细菌群体感应的特异性AI-2拮抗剂的化合物和组合物。尽管根据本发明的AI-2拮抗剂可能不具有杀菌作用，但是它们减弱毒力，耐药性和/或生物膜形成的能力具有治疗益处。另外，本公开的AI-2拮抗剂也可以用作探测细菌AI-2功能的工具。本公开内容还包括用于抑制或减弱微生物毒力，生物膜形成和耐药性的方法。该方法适合于防止细菌积聚并形成广泛的生物膜，这些生物膜可能对健康或卫生造成危害或存在物理问题，例如在水或燃料管路的堵塞中。

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