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ESTIMATION OF RECENT SHARED ANCESTRY

机译:最近共享祖先的估计

摘要

Methods and systems are described for the estimation of recent shared ancestry (ERSA) from the number and lengths of identical-by-descent (IBD) nucleotide segments derived from, e.g., high-density single-nucleotide polymorphism data or whole-genome sequence data. ERSA is accurate to within one degree of relationship for 97% of first- through fifth-degree relatives and 80% of sixth- and seventh-degree relatives. ERSA's statistical power approaches the maximum theoretical limit imposed by the fact that distant relatives frequently share no DNA through a common ancestor. ERSA greatly expands the range of relationships that can be estimated from genetic data.
机译:描述了用于根据衍生自例如高密度单核苷酸多态性数据或全基因组序列数据的后代相同(IBD)核苷酸片段的数目和长度来估计最近共享血统(ERSA)的方法和系统。 ERSA对于一级至五级亲戚的97%和六级和七级亲戚的80%的关系准确度在一个关系内。 ERSA的统计能力接近理论上的最大极限,该事实是远方亲戚通常不通过共同祖先共享任何DNA的事实。 ERSA极大地扩展了可以从遗传数据估计的关系范围。

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