首页> 外国专利> Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs

Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs

机译:缺血性损伤后使用基于Omega-3脂质的乳剂在人体器官中提供保护和恢复

摘要

The present invention provides methods of limiting cell death or damage or reperfusion damage resulting from hypoxic-ischemia, comprising administering an omega-3 triglyceride emulsion after a hypoxic-ischemia insult. The omega-3 triglyceride emulsion preferably comprises from about 7% to 35% omega-3 oil by weight in grams per 100 ml of emulsion; the omega-3 oil comprises about 20% to 100% triglyceride by weight per total weight of the omega-3 oil and about 20% wt.-% to 100% of the acyl-groups of the omega-3 triglycerides consist of DHA; the omega-3 oil comprises less than 10% omega-6 fatty acids; and the mean diameter of lipid droplets in the emulsion is less than about 5 microns.
机译:本发明提供了限制由缺氧缺血引起的细胞死亡或损伤或再灌注损伤的方法,包括在缺氧缺血损伤后给予omega-3甘油三酸酯乳剂。每100ml乳液中,以重量计,omega-3甘油三酸酯乳液优选包含约7重量%至35%重量的omega-3油;相对于omega-3油的总重量,omega-3油包含约20%至100%重量的甘油三酸酯和omega-3甘油三酸酯的约20%wt。%至100%的酰基由DHA组成; omega-3油包含少于10%的omega-6脂肪酸;乳剂中脂质滴的平均直径小于约5微米。

著录项

  • 公开/公告号US2014287004A1

    专利类型

  • 公开/公告日2014-09-25

    原文格式PDF

  • 申请/专利权人 RICHARD J. DECKELBAUM;

    申请/专利号US201414299440

  • 发明设计人 RICHARD J. DECKELBAUM;

    申请日2014-06-09

  • 分类号A61K31/202;A61K9/107;

  • 国家 US

  • 入库时间 2022-08-21 16:08:54

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