首页> 外国专利> CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME

CYCLIC PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME

机译:环肽低聚物,药物组合物及其使用方法

摘要

Novel peptoid oligomers are disclosed that have a formula represented by the following formula I:; embedded image ;wherein R1 and n are as described herein. The peptoids demonstrate antimicrobial and antimalarial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial or malarial infection is involved. The present cyclic peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
机译:公开了具有由下式I表示的式的新型拟肽低聚物: “嵌入式图像” ;其中R 1 和n如本文所述。类肽显示抗微生物和抗疟疾活性,并且可以制备为药物组合物,并用于预防或治疗哺乳动物(包括涉及微生物或疟疾感染的人)的多种病症。本发明的环状类肽特别有价值,因为它们的作用是快速的,谱广的并且对标准抗生素引起的抗性几乎无动于衷。

著录项

  • 公开/公告号US2014274916A1

    专利类型

  • 公开/公告日2014-09-18

    原文格式PDF

  • 申请/专利权人 KENT KIRSHENBAUM;MIA L. HUANG;

    申请/专利号US201414208235

  • 发明设计人 KENT KIRSHENBAUM;MIA L. HUANG;

    申请日2014-03-13

  • 分类号C07K7/64;

  • 国家 US

  • 入库时间 2022-08-21 16:09:59

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