Genetically modified non-human animals and cells that change the expression level of ATP1B1, methods for evaluating blood pressure-regulating substances and blood pressure-regulating conditions using the non-human animals and cells, and methods for regulating blood pressure using the mechanism provide. Non-human animals and cells have a functional genetic modification in the Dec1 or Dec2 gene, and the expression level of ATP1B1 is increased or decreased. The method for evaluating a blood pressure regulator includes a step of administering a test substance to the non-human animal. Alternatively, the method includes a step of bringing the test substance into contact with the cells. The method for evaluating blood pressure regulation conditions includes a step of placing the non-human animal and cells under test conditions. The method for regulating blood pressure includes a step of promoting or suppressing the transcriptional activity of the ATP1B1 gene in at least one of DEC1 or DEC2, and CLOCK, BMAL1, CRY1, and other clock transcription factors in a non-human animal. .
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