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Mizoribine tablets with improved color change

机译：咪唑立滨片具有改善的颜色变化

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摘要

PPROBLEM TO BE SOLVED: To provide a further excellent tablet containing mizoribine in accordance with various requirements potentially required from now in a medicinal scene. PSOLUTION: The mizoribine tablet comprises a core material containing mizoribine anhydride as an active ingredient and a pharmaceutically acceptable film-coating base material (a mixture of hydroxypropylmethylcellulose, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose or hydroxypropylmethylcellulose and ethylcellulose or ethylcellulose dispersion), for coating the core material, preventing color tone change of mizoribine by nitrogen oxide, and is characterized by having 30 min of disintegrating time, the mizoribine tablet has a color difference delta E of not more than 3 as a change of color tone on the surface of the core material, measured by a color difference meter before and after leaving to stand for 1 hour in an atmosphere of about 25 ppm nitrogen oxide. PCOPYRIGHT: (C)2011,JPO&INPIT

机译：

要解决的问题：根据医学领域从现在起可能需要的各种要求，提供一种含米唑啉碱的进一步优异的片剂。

解决方案：咪唑啉碱片剂包含以咪唑啉碱酐为有效成分的核心材料和可药用的薄膜包衣基质材料（羟丙基甲基纤维素，甲基纤维素，羟丙基纤维素，羟丙基甲基纤维素邻苯二甲酸酯，羟丙基甲基纤维素乙酸琥珀酸酯，羧甲基乙基纤维素或羟丙基甲基纤维素或羟丙基甲基纤维素或羟丙基甲基纤维素或羟丙基甲基纤维素）（乙基纤维素分散体）或乙基纤维素分散体）用于包衣核心材料，防止氮氧化氮导致咪唑立滨的色调变化，并且具有30分钟的崩解时间，该咪唑立汀片的色差差E不大于3在约25 ppm的氮氧化物气氛中放置1小时之前和之后，用色差计测量芯材表面的色调。

版权：（C）2011，日本特许厅＆INPIT 展开▼

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公开/公告号JP5350436B2

专利类型
公开/公告日2013-11-27

原文格式PDF
申请/专利权人旭化成ファーマ株式会社;
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申请/专利号JP20110141522
发明设计人鈴木一美;住田行男;
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申请日2011-06-27
分类号A61K31/7056;A61K9/36;A61K47/32;A61K47/38;A61P13/12;A61P19/02;A61P29;A61P37/06;
国家 JP
入库时间 2022-08-21 16:11:18

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