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Synthesis of block copolymer of poly ((lactic acid-co-glycolic acid) -b-lysine) and PLGA {poly (lactic acid-co-glycolic acid)} and PLL (poly-ε-Cbz-L-lysine) Method
Synthesis of block copolymer of poly ((lactic acid-co-glycolic acid) -b-lysine) and PLGA {poly (lactic acid-co-glycolic acid)} and PLL (poly-ε-Cbz-L-lysine) Method
A method of synthesizing copolymers is provided. The method can include coupling a degradable polymer to a poly(amino acid) and then deprotecting the copolymer if the poly(amino acid) contains protected side chains. Copolymer compositions are provided. These compositions include PLGA-PLL copolymers, PLGA-PLL-cbz copolymers, and copolymers of a polyester with a carboxylic acid end group coupled to a poly(amino acid) with an amine group. The compositions may include therapeutic blends and formulations of copolymers.
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