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METHOD OF PRODUCING (E)-1-HALO-ENAMIDE DERIVATIVE OR ITS SALT AND (E)-1-HALO-ENAMIDE DERIVATIVE OR ITS SALT
METHOD OF PRODUCING (E)-1-HALO-ENAMIDE DERIVATIVE OR ITS SALT AND (E)-1-HALO-ENAMIDE DERIVATIVE OR ITS SALT
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机译：（E）-1-卤代酰胺衍生物或其盐和（E）-1-卤代酰胺衍生物或其盐的制备方法
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摘要
PROBLEM TO BE SOLVED: To provide a production method which allows easy acquisition of (E)-1-halo-enamide derivatives with high purity and is applicable to reactions on the gram scale and novel (E)-1-halo-enamide derivatives.;SOLUTION: A method of producing (E)-1-halo-enamide derivatives or their salts comprises causing an ynamide derivative of formula (I), a halosilane of formula (II) and a proton donor of formula (III) to react to form an (E)-1-halo-enamide derivative of formula (IV). In the formulae, A is an aromatic or aliphatic hydrocarbon group; (1) B and D form a ring containing the nitrogen atom adjacent to them or (2) B is an electron-withdrawing group and D is a hydrogen atom or an aromatic or aliphatic hydrocarbon group; R1 is a hydrogen atom or a hydrocarbon group; and X is halogen.;COPYRIGHT: (C)2014,JPO&INPIT
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机译：解决的问题：提供一种易于获得高纯度的（E）-1-卤代酰胺衍生物的生产方法，并适用于克级和新型（E）-1-卤代酰胺衍生物的反应。 ;解决方案：制备（E）-1-卤代酰胺衍生物或其盐的方法包括使式（I）的炔酰胺衍生物，式（II）的卤代硅烷和式（III）的质子供体反应为形成式（IV）的（E）-1-卤代酰胺衍生物。式中，A为芳香族或脂肪族烃基。 （1）B和D形成与它们相邻的含氮原子的环，或（2）B是吸电子基团，D是氢原子或芳族或脂族烃基; R 1 为氢原子或烃基; X是卤素。;版权所有：（C）2014，JPO＆INPIT
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