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METHOD FOR PREDICTION OF POPULATION BIOTRANSFORMATION DISORDERS OF FOREIGN SUBSTANCES CAUSED BY EXPOSURE TO MAN-INDUCED CHEMICAL HABITAT FACTORS

机译：人为诱发的化学生境因子暴露引起的外国物质的人口生物转化疾病的预测方法

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FIELD: medicine.;SUBSTANCE: what is presented is a method for prediction of the population biotransformation disorders of foreign substances caused by the exposure to man-induced chemical habitat factors. One ethnic population living on the territory of the exposure to hazardous chemical factors is sampled; buccal epithelium is sampled; DNA is recovered that is followed by genotyping of the polymorphous version 9893A/G of CYP1A1 gene, 921A/C of CPOX gene, and G308A of TNF-alpha gene; one of the following gene conditions are stated: heterozygous, normal homozygous or minor homozygous; a prevalence ratio of the minor alleles for the genes studied is calculated by formula; and the population disorders are predicted.;EFFECT: invention enables the accurate and reliable prediction of the population biotransformation disorders of foreign substances caused by the exposure to man-induced chemical habitat factors and may be used for providing the preventive ways to protect and stabilise an ethnic population genome in conditions of the increasing environmental pollution.;2 tbl, 1 ex

机译：领域：医学;物质：提出了一种预测由于暴露于人为诱导的化学栖息地因素而引起的外来物质的生物转化异常的方法。对生活在危险化学因子暴露地区的一个种族人口进行了抽样;颊上皮取样;回收DNA，然后对CYP1A1基因的多态性版本9893A / G，CPOX基因的921A / C和TNF-alpha基因的G308A进行基因分型;说明了以下基因条件之一：杂合，正常纯合或轻度纯合;通过公式计算出所研究基因的次要等位基因的患病率;效果：本发明能够准确和可靠地预测由于暴露于人为化学栖息地因素而引起的外来物质的人口生物转化疾病，并且可以用于提供保护和稳定人类的预防方法。环境污染日益严重的情况下的少数民族人口基因组。; 2 tbl，1 ex

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公开/公告号RU2497120C1

专利类型
公开/公告日2013-10-27

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申请/专利权人 FEDERALNOE BJUDZHETNOE UCHREZHDENIE NAUKI FEDERALNYJ NAUCHNYJ TSENTR MEDIKO-PROFILAKTICHESKIKH TEKHNOLOGIJ UPRAVLENIJA RISKAMI ZDOROVJU NASELENIJA (FBUN FNTS MEDIKO-PROFILAKTICHESKIKH TEKHNOLOGIJ UPRAVLENIJA RISKAMI ZDOROVJU NASELENIJA);
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申请/专利号RU20120134336
发明设计人 LANIN DMITRIJ VLADIMIROVICH;GUGOVICH ALESJA MIKHAJLOVNA;ZAJTSEVA NINA VLADIMIROVNA;KHARAKHORINA REGINA ATLASOVNA;DIANOVA DINA GUMJAROVNA;LYKHINA TATJANA STANISLAVOVNA;KRIVTSOV ALEKSANDR VLADIMIROVICH;DOLGIKH OLEG VLADIMIROVICH;
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申请日2012-08-10
分类号G01N33/50;
国家 RU
入库时间 2022-08-21 16:22:45

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