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BIOLOGICALLY ACTIVE SUBSTANCES SUPPRESSING PATHOGENIC BACTERIA, AND METHOD FOR INHIBITING TYPE III SECRETION IN PATHOGENIC BACTERIA

机译:抑制致病性细菌的生物活性物质,以及抑制致病性细菌中III型分泌的方法

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to indolyl-substituted derivatives of thiadiazinones prepared from oxamic acid thiohydrazide of general formula: , wherein R represents H; R1 represents pyridinyl; phenyl substituted by alkyl C1-C5, Hal, CF3; R2 represents H; alkyl C1-C5; -CH2COOR4; benzyl substituted by Hal, OR4; benzoyl substituted by Hal, OR4, while R4 represents unsubstituted alkyl C1-C4.;EFFECT: there are prepared new compound which can find application in medicine for developing the therapeutic agent possessing pathogenic bacteria inhibitory activity.;2 cl, 2 dwg, 2 tbl, 13 ex
机译:技术领域:发明是指由草酰胺酸硫酰肼制备的噻二嗪酮的吲哚基取代的衍生物,其通式为: “ wi =“ 66” />,其中R代表H; R 1 代表吡啶基;被烷基C1-C5,Hal,CF 3 取代的苯基; R 2 代表H;烷基C1-C5; -CH 2 COOR 4 ;被Hal,OR 4 取代的苄基; Hal,OR 4 取代苯甲酰基,R 4 代表未取代的烷基C1-C4。具有病原菌抑制活性的药物;; 2 cl,2 dwg,2 tbl,13 ex

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