10 m.c./cm3 on a gamma-installation in a dose of 140-150 Gr with following thermostating and extraction of radiotoxin with 70% acidified with 0.05% hydrochloric acid to pH 5.5 ethanol, following evaporation of the exractant to the initial volume, after that, obtaining protein-cadmium radioantigen first by preliminary dechlorination of cadmium chloride, obtaining cadmium hydroxide, addition into the obtained 2.7% solution of the antigen of 0.77% solution of cadmium hydroxide in a ratio of 1:1 with following thermostating at a temperature of 37°C for 30 minutes, evaporation and dissolution of the residue to 12.8% concentration, further obtaining protein-cadmium radioantigen by an addition of 1.2% solution of a mixture of three anatoxins of E.coli and 12.8% solution of cadmium radioantigen in a ratio of 1:9, conjugation of components at room temperature for 8-10 hours, standardisation by a dry substance to 10% concentration and pouring into vials, and storage at a temperature of 4-6°C. The group of inventions also relates to a method of treating radiation, chemical and/or bacteriological damage to an organism by introduction of 10% solution of complex protein-cadmium radioantigen.;EFFECT: application of the group of inventions is effective in treatment of radiation, chemical and/or biological damage.;4 cl, 6 ex"/>
公开/公告号RU2011150766A
专利类型
公开/公告日2013-06-20
原文格式PDF
申请/专利号RU20110150766
发明设计人 ИВАНОВ АРКАДИЙ ВАСИЛЬЕВИЧ (RU);КОНЮХОВ ГЕННАДИЙ ВЛАДИМИРОВИЧ (RU);ГАЙЗАТУЛЛИН РИНАТ РАУФОВИЧ (RU);ПЛОТНИКОВА ЭДИЕ МИНАЧЕТДИНОВНА (RU);НЕФЕДОВА РИММА ВЛАДИМИРОВНА (RU);ИВАНОВ АЛЕКСАНДР АРКАДЬЕВИЧ (RU);НИЗАМОВ РАМЗИ НИЗАМОВИЧ (RU);
申请日2011-12-13
分类号A61K39/00;
国家 RU
入库时间 2022-08-21 16:23:43