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Preparation Method of the Inclusion Complex of Peracetylated Cyclodextrin and Water-Soluble Drugs formed in Supercritical Carbon Dioxide and Use Thereof
Preparation Method of the Inclusion Complex of Peracetylated Cyclodextrin and Water-Soluble Drugs formed in Supercritical Carbon Dioxide and Use Thereof
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机译:全乙酰化环糊精与超临界二氧化碳形成的水溶性药物包合物的制备方法及其用途
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摘要
PURPOSE: A method for manufacturing an inclusion complex of peracetylated cyclodextrin or heptakis(2,3,6-tri-O-acetyl) cyclodextrin and soluble drugs is provided to enhance inclusion rate and to apply in oral administration. CONSTITUTION: A method for manufacturing an inclusion complex of peracetylated cyclodextrin and soluble drugs comprises: a step of stirring peracetylated cyclodextrin(PAc-CD) and soluble drugs to form an inclusion; a step of removing supercritical carbon dioxide. Peraceylated cyclodextrin is PAc-alpha-CD, PAc-beta-CD, or PAc-gamma-CD. A pharmaceutical composition contains the inclusion complex.
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