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首页> 外国专利> USE OF SERUM PROTEIN FETUIN-B AS BIOMAKER FOR DIAGNOSIS OF ST SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI)

USE OF SERUM PROTEIN FETUIN-B AS BIOMAKER FOR DIAGNOSIS OF ST SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI)

机译：血清蛋白牛血清白蛋白B作为诊断ST段抬高性心肌梗死（STEMI）的生物标志物

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The present invention relates to a biomarker for diagnosis of human ST segment elevation myocardial infarction (STEMI) and, more specifically, the use of Fetuin-B as a biomarker for early diagnosis of STEMI using a characteristic that the Fetuin-B expression in patients with STEMI is significantly increased than patients with stable angina. The present invention enables the preliminary diagnosis of STEMI which is still cryptogenic using the serum protein Tetuin-B of STEMI patients. The Fetuin-B protein according to the present invention is used for the development of diagnosis kit and medicine for STEMI since the Fetin-B promotes T-cell migration and enhances matrix metalloproteinases(MMP)-2?‹ which is associated with the rupture of atheromatous plaque, and remarkably increases in the serum of STEMI patients compare with the same of stable angina patients, thereby being used as the biomarker for STEMI.;COPYRIGHT KIPO 2014
机译：本发明涉及一种用于诊断人ST段抬高型心肌梗塞（STEMI）的生物标志物，更具体地，涉及一种Fetuin-B作为一种早期诊断STEMI的生物标志物的用途，其特征在于： STEMI明显高于稳定型心绞痛患者。本发明能够使用STEMI患者的血清蛋白Tetuin-B对仍是隐源性的STEMI进行初步诊断。本发明的Fetuin-B蛋白用于STEMI的诊断试剂盒和药物的开发，因为Fetin-B促进T细胞迁移并增强与金属蛋白酶破裂有关的基质金属蛋白酶（MMP）-2β。动脉粥样硬化斑块，与稳定型心绞痛患者相比，STEMI患者的血清显着增加，因此可用作STEMI的生物标志物。; COPYRIGHT KIPO 2014

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