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MANUFACTURING METHOD OF THE BENZODIAZEPINE DERIVATIVE USED AS CORE INTERMEDIATE IN VARIOUS MEDICINE PRODUCTIONS INCLUDING THE SCHIZOPHRENIA THERAPEUTIC AGENT, THE ANTISPASMODIC, ETC.
MANUFACTURING METHOD OF THE BENZODIAZEPINE DERIVATIVE USED AS CORE INTERMEDIATE IN VARIOUS MEDICINE PRODUCTIONS INCLUDING THE SCHIZOPHRENIA THERAPEUTIC AGENT, THE ANTISPASMODIC, ETC.
PURPOSE: A manufacturing method of the benzodiazepine derivative is provided to offer a simple production process and economic benefits not by using the expensive catalyst, and to safely mass-produce the high-yield of benzodiazepine derivative as there is not in danger of ignition or explosion.;CONSTITUTION: A manufacturing method of the benzodiazepine derivative comprises the step of manufacturing the compound which is represented by the chemical formula 1 by the reduction reaction between a reducing agent and the compound represented by chemical formula 2. The above manufacturing method of the benzodiazepine derivative is performed by reacting the compound represented by chemical formula 2 with the reducing agent at a mol ratio of 1:0.5-1:10. The above reduction reaction occurs at 0 through 100°C. The above compound represented by chemical formula 2 is manufactured by cyclizing the compound represented by chemical formula 3 under the presence of base basic condition. The base is the one of the group comprised of sodium hydroxide and potassium hydroxide.;COPYRIGHT KIPO 2013
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