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CELL KILLING FUSION PEPTIDE HAVING CANCER CELL-SPECIFIC NECTROSIS AND TUMOR REGRESSION EFFECTS

机译:具有杀伤细胞特异性杀伤作用的细胞杀伤融合肽和肿瘤消退作用

摘要

PURPOSE: An apoptosis-inducing fusion peptide which induces cancer cell-specific necrosis and removes cancer is provided to strongly cause apoptosis of a cancer cell line and to enable strong tumor regression. CONSTITUTION: A cancer-targeting apoptosis-inducing fusion peptide comprises: cancer cell targeting domain(CTD; R1-R7) containing an amino acid sequence of Arg-Xaa-Xaa-Arg-Xaa-Xaa-Arg; a linker sequence with an amino acid sequence of n=0-5; and a cell killing peptide(CKP) containing an amino acid sequence of sequence number 21(KLLNLISKLF) or an amino acid sequence with 70% or more of homology. A DNA or RNA oligonucleotide encodes the cancer-targeting apoptosis-inducing fusion peptide. [Reference numerals] (AA,DD) CTD domain(R1R2R3....R7); (BB,CC) CKP domain(KLLNLISKLF)
机译:目的:提供一种诱导凋亡的融合肽,其诱导癌细胞特异性坏死并去除癌症,以强烈引起癌细胞系的凋亡并实现强烈的肿瘤消退。组成:一种靶向癌细胞凋亡的融合肽包括:癌细胞靶向结构域(CTD; R1-R7),其包含氨基酸序列Arg-Xaa-Xaa-Arg-Xaa-Xaa-Arg。具有n = 0-5个氨基酸序列的接头序列;杀伤肽(CKP),其含有序列号21的氨基酸序列(KLLNLISKLF)或具有70%以上同源性的氨基酸序列。 DNA或RNA寡核苷酸编码靶向癌症的凋亡诱导融合肽。 [参考数字](AA,DD)CTD域(R1R2R3 .... R7); (BB,CC)CKP域(KLLNLISKLF)

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