首页> 外国专利> TREATMENT OF VASCULAR DISEASES USING ENCAPSULATED CELLS ENCODING AND SECRETING GLP-1, OR A FRAGMENT OR VARIANT THEREOF

TREATMENT OF VASCULAR DISEASES USING ENCAPSULATED CELLS ENCODING AND SECRETING GLP-1, OR A FRAGMENT OR VARIANT THEREOF

机译:使用编码和分泌GLP-1的囊化细胞或其片段或多种形式治疗血管疾病

摘要

The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting at least GLP-1, or a fragment or variant thereof, and preferably additionally secreting VEGF, for the prevention, treatment and/or amelioration of vascular diseases, wherein the cells, encoding and secreting at least GLP-1, or a fragment or variant thereof, and preferably additionally secreting VEGF, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the prevention, treatment and/or amelioration of vascular diseases.
机译:本申请涉及细胞的使用,例如细胞。间充质干细胞或间充质基质细胞,或编码和分泌至少GLP-1或其片段或变体,并优选另外分泌VEGF的任何合适的细胞,用于预防,治疗和/或改善血管疾病,其中将编码和分泌至少GLP-1或其片段或变体,并且优选另外分泌VEGF的细胞封装在(球形)微胶囊中,以防止待治疗患者的免疫系统反应。本申请还涉及这些(球形)微囊或包含这些细胞或(球形)微囊的药物组合物在预防,治疗和/或改善血管疾病中的用途。

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