首页> 外国专利> HYPOGLYCEMIC ENCEPHALOPATHY MODEL AND METHOD FOR PRODUCING SAME, NEUROPROTECTIVE AGENT SCREENING METHOD, AND NEUROPROTECTIVE AGENT

HYPOGLYCEMIC ENCEPHALOPATHY MODEL AND METHOD FOR PRODUCING SAME, NEUROPROTECTIVE AGENT SCREENING METHOD, AND NEUROPROTECTIVE AGENT

机译：降血糖的脑血管病模型和生产方法，神经保护剂筛选方法和神经保护剂

页面导航

摘要
著录项
相似文献

摘要

Provided is a neuroprotective agent screening method comprising an administration step for administering glucose and a test substance to a hypoglycemic encephalopathy model, which is a non-human animal having a flat electroencephalogram and at least one symptom selected from the group consisting of loss of light reflex, dilated pupils, and convulsions, and a screening step for screening as a neuroprotective agent a test substance capable of inhibiting induction of at least one selected from the group consisting of generation of cytotoxic aldhehyde in brain cells and neuron degeneration. Also provided is a hypoglycemic encephalopathy model that is used in the screening method and a method for producing the same.

机译：提供了一种神经保护剂筛选方法，其包括用于将葡萄糖和测试物质给予降血糖性脑病模型的给药步骤，所述降血糖性脑病模型是具有平坦脑电图和选自光反射丧失的至少一种症状的非人类动物。，散瞳和抽搐，以及筛选步骤，其筛选能够抑制至少一种选自脑细胞中的细胞毒性醛和神经元变性的诱导物的测试物质作为神经保护剂。还提供了在筛选方法中使用的降血糖性脑病模型及其制备方法。

著录项

公开/公告号WO2013125722A1

专利类型
公开/公告日2013-08-29

原文格式PDF
申请/专利权人 NIIGATA UNIVERSITY;
展开▼

申请/专利号WO2013JP54813
发明设计人 SHIMOHATA TAKAYOSHI;
展开▼

申请日2013-02-25
分类号A01K67;A61K31/36;A61K31/7004;A61P3/08;A61P25;A61P25/28;A61P43;G01N33/15;G01N33/50;
国家 WO
入库时间 2022-08-21 16:31:07

相似文献

专利
外文文献
中文文献