首页> 外国专利> METHOD FOR THE SURFACE TREATMENT OF TITANIUM BONE IMPLANTS USING A SODIUM HYDROXIDE BATH TO ENHANCE THE OSSEOINTEGRATION THEREOF

METHOD FOR THE SURFACE TREATMENT OF TITANIUM BONE IMPLANTS USING A SODIUM HYDROXIDE BATH TO ENHANCE THE OSSEOINTEGRATION THEREOF

机译:用氢氧化钠浴表面处理钛骨植入物以增强其骨整合的方法

摘要

The invention relates to a method for the surface treatment of a biologically inert titanium implant to be placed in contact with a bone of the human body, which involves allowing bodily fluids, such as the inorganic portion of human blood plasma, to naturally deposit, onto the titanium implant, a calcium phosphate film having the formula Ca5(PO4)3(OH), in the form of hydroxyapatite, with a view to rendering the biologically inert titanium biologically active so as to enable a the bone to be chemically bonded to the implant, thus promoting osseointegration, wherein the method includes an operation that involves submerging the titanium implant in a sodium hydroxide (NaOH) solution, the concentration of which is around 10 moles per liter, said submersion causing the formation of a hydrated titanium oxide (HTiO3-) film on the titanium, which in turn causes hydroxyl groups (TiOH) to appear, thereby enabling the deposition of said calcium phosphate film. The method according to the invention is characterized in that the operation of submerging the implant in the sodium hydroxide is preceded by an operation for pickling said implant with a fluoronitric acid solution, in that, during the submersion operation, the temperature of the sodium hydroxide solution is between 60°C and 100°C, and in that the duration of said submersion operation is less than eight hours.
机译:本发明涉及一种用于生物惰性钛植入物的表面处理的方法,该植入物被放置成与人体的骨骼接触,该方法涉及允许诸如人体血浆的无机部分的体液自然地沉积到其上。钛植入物,其为羟基磷灰石形式的分子式为Ca 5 (PO 4 3 (OH)的磷酸钙膜,为了使生物惰性钛具有生物活性,以使骨骼化学键合到植入物上,从而促进骨整合,其中该方法包括将钛植入物浸入氢氧化钠(NaOH)溶液中的操作,浓度约为10摩尔/升,所述浸没会在钛上形成水合氧化钛(HTiO 3 -)膜,进而导致羟基(TiOH)出现,从而使所述磷酸钙沉积电影。根据本发明的方法的特征在于,在将植入物浸入氢氧化钠之前,先进行用氟硝酸溶液对所述植入物进行酸洗的操作,其中,在浸入操作期间,将氢氧化钠溶液的温度升高。温度在60℃至100℃之间,并且所述浸入操作的持续时间少于八小时。

著录项

  • 公开/公告号WO2013072577A1

    专利类型

  • 公开/公告日2013-05-23

    原文格式PDF

  • 申请/专利权人 OBL (SOCIETE ANONYME);

    申请/专利号WO2012FR00459

  • 发明设计人 BARBAS ALEXANDRE;

    申请日2012-11-14

  • 分类号A61L27/06;C23C22/64;A61L27/32;

  • 国家 WO

  • 入库时间 2022-08-21 16:33:03

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