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ANTI-HLA-DR ANTIBODIES SUPPRESS ALLOGENEIC AND XENOGENEIC IMMUNE RESPONSES TO ORGAN TRANSPLANTS
ANTI-HLA-DR ANTIBODIES SUPPRESS ALLOGENEIC AND XENOGENEIC IMMUNE RESPONSES TO ORGAN TRANSPLANTS
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机译：抗HLA-DR抗体抑制器官移植的同种和异种免疫反应。
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摘要
Disclosed herein are methods and compositions comprising anti-HLA-DR antibodies for treatment of allogeneic and xenogeneic immune responses occurring in organ transplant rejection and other immune dysfunction diseases. In preferred embodiments, the anti-HLA-DR antibodies are effective to deplete antigen-presenting cells, such as dendritic cells. Most preferably, administration of the therapeutic compositions depletes all subsets of APCs, including mDCs, pDCs, B cells and monocytes, without significant depletion of T cells. In alternative embodiments, administration of the therapeutic compositions suppresses proliferation of allo-reactive T cells, while preserving cytomegalovirus (CMV)-specific, CD8+ memory T cells. The compositions and methods provide a novel therapeutic agent for suppressing or preventing allogeneic or xenogeneic immune responses, without altering preexisting anti-viral immunity.
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