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MODULATORS OF THE NLRP3 INFLAMMASOME IL-1ß PATHWAY FOR THE PREVENTION AND TREATMENT OF ACNE

机译：预防和治疗痤疮的NLRP3炎性IL-1ß途径的调节剂

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摘要

The invention provides inhibitors capable of binding to a member of the inflammasome group comprised of IL-1 β, IL-1 receptor type 1, NLRP3, ASC, Caspase-1 and cathepsin B with a dissociation constant of 10^-8 mol/l or smaller for the prevention and treatment of acne, specifically an antibody, an antibody fragment, an antibody-like molecule, an oligopeptide of 6 to 30 amino acid residues, a nucleic acid aptamer molecule of 10 to 75 nucleotides in length or a soluble polypeptide comprising a contiguous amino acid sequence of at least 30 amino acids comprised within the protein sequence of a member of the group comprised of IL-1 β, IL-1 receptor type 1, IL-1 receptor type 2, NLRP3, ASC and Caspase-1. Similarly, an interfering RNA or an antisense modulator of gene expression of IL-1 β, I L-1 β receptor type 1, NLRP3, ASC, Caspase-1 and cathepsin B are provided for the prevention or treatment of acne.

机译：本发明提供了能够结合解离常数为10 Sup -8的抑制剂结合由IL-1β，IL-1 1型，NLRP3，ASC，Caspase-1和组织蛋白酶B组成的炎性体组的成员。 / Sup> mol / l或更小，用于预防和治疗痤疮，特别是抗体，抗体片段，抗体样分子，6至30个氨基酸残基的寡肽，10至75个核苷酸的核酸适体分子长度或包含至少30个氨基酸的连续氨基酸序列的可溶性多肽，该序列包含在IL-1β，IL-1受体1型，IL-1受体2型， NLRP3，ASC和Caspase-1。类似地，提供IL-1β，IL-1β受体1型，NLRP3，ASC，Caspase-1和组织蛋白酶B的基因表达的干扰RNA或反义调节剂，用于预防或治疗痤疮。

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公开/公告号WO2013007763A1

专利类型
公开/公告日2013-01-17

原文格式PDF
申请/专利权人 UNIVERSITÄT ZÜRICH;JANKOVIC DRAGANA;KISTOWSKA MAGDALENA;CONTASSOT EMMANUEL;FRENCH LARS. E.;GEHRKE SAMUEL;
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申请/专利号WO2012EP63617
发明设计人 JANKOVIC DRAGANA;KISTOWSKA MAGDALENA;CONTASSOT EMMANUEL;FRENCH LARS. E.;GEHRKE SAMUEL;
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申请日2012-07-11
分类号C07K16/24;C07K16/28;A61K31/64;A61P17/10;A61K31/7088;
国家 WO
入库时间 2022-08-21 16:35:30

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